Is it chance or synchronicity that brings “Bernhardt/Hamlet,” a muscular comedy about a woman unbound, to Broadway at this grim transitional moment in gender politics?

Either way, Theresa Rebeck’s new play, which opened on Tuesday at the American Airlines Theater, is so clever it uplifts, so timely it hurts.

What a pleasure it is to watch a pair of acting pros like Angelica Huston and Bill Pullman, both in tip-top form, duke it out as embattled siblings in the pithily titled “Trouble.” It’s a film that begins as a raucous rural comedy and deftly evolves into a poignant and reflective, yet still wryly amusing, story of what becomes of a family.